Yoko Nagai
Genome Researcher
Bioinformatics and molecular biologist
CAREER & EDUCATION
Feb 2017 - present
バリノス株式会社 共同創業者、CTO
Co-founder, CTO
Varinos Inc, Japan
Jul 2014 - Feb 2017
イルミナ株式会社 リサーチ営業本部 シーケンシングスペシャリスト
Sequencing Specialist, Sales Department
Illumina KK, Tokyo, Japan
Mar 2013 - Jun 2014
東海大学医学部 基礎医学系分子生命科学 研究員
Postdoctoral Research fellow, Biomedical Informatics Laboratory,
Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science,Tokai University School of Medicine, Kanagawa, Japan
Apr 2011 - Fub 2013
産業技術総合研究所 バイオメディシナル情報研究センター分子システム情報統合チーム 研究員
Postdoctoral Research Fellow, Integrated Database and Systems Biology Team, Biomedicinal Information Research CenterNational Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan
Apr 2008 - Mar 2011
東京大学大学院薬学部 博士課程修了
Ph.D., Department of Pharmaceutical Sciences, Tokyo University, Tokyo, JapanApr 2006 - Mar2008
M.Sc., Department of Developmental and Regenerative Biology, Tokyo Medical and Dental University,Tokyo, Japan
Apr 2002 – Mar 2006
Department of Molecular Biology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
INTERVIEWS & REVIEWS
「Varinos Inc. – Q&A with a Japanese biotech start-up」DNA Genotek's Microbiome Collection and Stabilization Blog, 2018年10月11日
「医薬調査のバリノス、子宮の細菌検査 不妊治療に活用」日本経済新聞 2018年1月29日
- 「子宮内の菌叢解析手掛けるVarinos、2億円の第三者割当増資を実施」高橋厚妃. 日経バイオテクONLINE 2018年1月29日
- 「 新春展望2018 新規バイオマーカー探索が続々」高橋厚妃. 日経バイオテクONLINE 2018年1月4日
- 「ゲノム医療の実用化目指し、元イルミナ社員がベンチャーのVarinosを起業」橋本宗明. 日経バイオテクONLINE 2017年7月31日
- 「話題の検査 : 子宮内フローラ検査 子宮内フローラ検査で、不妊から不育の原因を探る 」長井 陽子. 医療と検査機器・試薬 41巻3号(2018年6月10号)
- 「NGS企業のロードマップ」長井 陽子. 実験医学 Vol.34 No.16 (10月号) 2676-2677. 2016
- 「次世代シーケンサーを用いたマイクロバイオーム研究の最前線」長井 陽子, 鈴木 健介. 日本臨床化学会 臨床化学 Vol.44 No.4 269-274. 2015
PUBLICATIONS
- Kyono K, Hashimoto T, Kikuchi S, Nagai Y, Sakuraba Y. A pilot study and case reports on endometrial microbiota and pregnancy outcome: An analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium. Reprod Med Biol. 2018 Oct 25;18(1):72-82.
- Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: A single-center pilot study. Reprod Med Biol. 2018 May 6;17(3):297-306.
- Asaoka Y, Nagai Y, Namae M, Furutani-Seiki M, Nishina H. SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling. BBRC. 2017; 474(1):146-153
- Yamada C, Kondo M, Kishimoto N, Shibata T, Nagai Y, Imanishi T, Oroguchi T, Ishii N, Nishizaki Y. Association between insulin resistance and plasma amino acid profile in non‐diabetic Japanese subjects. J Diabetes Investigation 2015; 6(4): 408-415
- Nagai Y, Takahashi Y, Imanishi T. VaDE: a manually curated database of reproducible associations between various traits and human genomic polymorphisms. Nucleic acids research, Database Issue 43(D1): D868-872, Jan. 2014
- Nagai Y, Imanishi T. RAvariome: a genetic risk variants database for rheumatoid arthritis based on assessment of reproducibility between or within human populations. Database bat073. Oct. 2013
- Takeda J, Yamasaki C, Murakami K, Nagai Y, Sera M, Hara Y, Obi N, Habara T, Gojobori T, Imanishi T. H-InvDB in 2013: an omics study platform for human functional gene and transcript discovery. Nucleic Acids Research, Databases Issue 41(D1): D915-D919. Jan. 2013
- Imanishi T, Nagai Y, Habara T, Yamasaki C, Takeda J, Mikami S, Bando Y, Tojo H, Nishimura T. Full-length transcriptome-based H-InvDB throws a new light on chromosome-centric proteomics. Journal of Proteome Research, C-HPP Special Issue 12(1): 62-66. Jan. 2013
- Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H. p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem cells and development 19 1723-1734. Nov. 2010
- Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of cellular biochemistry 110 1022-1037. Jul. 2010
- Nagai Y, Asaoka Y, Namae M, Saito K, Momose H, Mitani H, Furutani-Seiki M, Katada T, Nishina H. The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochemical and Biophysical Research Communications 396 887-893. Jun. 2010
- Negishi T, Nagai Y, Asaoka Y, Ohno M, Namae M, Mitani H, Sasaki T, Shimizu N, Terai S, Sakaida I, Kondoh H, Katada T, Furutani-Seiki M, Nishina H. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology (Baltimore, Md.) 51 1037-1045. Mar. 2010
- Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, Noda E, Nishina S, Niwa H, Azuma N, Katada T, Nishina H. CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochemical and Biophysical Research Communications 390 1129-1135. Dec. 2009
WORKS
Developed databases at Tokai University School of Medicine and AIST
VaDE
VarySysDB Disease Edition (VaDE) is a literature based genetic trait and genomic information database.
Reproducible SNP-trait associations in each populations.
Significant SNP-trait associations reported in GWAS.
SNP related functional information.
RAvariome
RAvariome is a genetic risk variants database for rheumatoid arthritis (RA) based on assessment of reproducibility between or within human populations.
Confirmed RA genetic risk variants.
Genetic risk prediction tool for RA.
H-EPD
H-Inv Extended Protein Database (H-EPD) is a merged data set of H-Inv proteins and other protein databases and present a new strategy of database-driven proteome research that makes full use of transcriptome data.
SOCIETY
ゲノムビジネスミートアップ
Genome Business Meetup
2017年 開始予定
CONTACT
Copyright 2016